英文名:Acetyl-CoA Carboxylase-IN-1 描述: Acetyl-CoA Carboxylase-IN-1,一种有效的乙酰辅酶 A 羧化酶 (ACC) 抑制剂,具备抗菌活性,其 IC50 值小于 5 nM。 存储条件: Powder: -20°C for 3 years | In solvent: -80°C for 1 year 点击查看大图 ...
However, it also feeds mitochondrial anaplerotic pathways, driving citrate export and cytosolic malonyl-CoA production by the acetyl-CoA carboxylase 1 (ACC1) enzyme. This pathway has been proposed as an alternative glucose-sensing mechanism, supported mainly by in vitro data. Here, we sought to ...
A separate Phase 2 study is investigating treatment with GS-9674, the investigational apoptosis signal-regulating kinase 1 inhibitor selonsertib, and the investigational acetyl-CoA carboxylase inhibitor GS-0976 alone or in combination, in patients with advanced fibrosis due to NASH. Gilead presents Pha...
Acetyl-CoA carboxylase (ACC) catalyzes the production of malonyl-CoA which may act as a metabolic coupling factor in nutrient-induced insulin release. We have studied the long term regulation of ACC by nutrients using the cell line INS-1. Glucose, from 5 to 20 mM, elicited a 15-fold incre...
Fig. 1.The acetyl-CoA carboxylase reaction is performed in two steps. Biotin, covalently attached to BCCP (biotin carboxyl carrier protein,accB), is carboxylated by the carboxylase subunit (accC). The heterodimeric transcarboxylase (accAandaccD) then transfers the CO2to acetyl-CoA, forming malony...
The effects of consecutive feeding 8.1% fat diet for 12 weeks on serum biochemical indices,hepatopancreas biochemical indices and acetyl-CoA carboxylase 1(ACC1) mRNA expression of grass carp were investigated to study the metabolic regulation mechanism of grass carp liver on high-fat diet.A total...
Acetyl-CoA carboxylase-α (ACC-α) is a key enzyme in the regulation of fatty acid synthesis and is subject to both acute control, via reversible phos- phorylation, and chronic control that results in the reg- ulation of synthesis of the enzyme. The gene for ACC- α is expressed ...
Acetyl-CoA carboxylase (ACCase) catalyses the carboxylation of acetyl-CoA, forming malonyl-CoA, which is used in the plastid for fatty acid synthesis and in the cytosol in various biosynthetic pathways including fatty acid elongation. In Arabidopsis thaliana, ACC1 and ACC2, two genes locate...
Introduction: Acetyl-CoA Carboxylase (ACC) is an essential rate-limiting enzyme in fatty acid metabolism. For many years, ACC inhibitors have gained great attention for developing therapeutics for various human diseases including microbial infections, metabolic syndrome, obesity, diabetes, and cancer. Ar...
acetyl-CoA carboxylase; isoforms of acetyl-CoA carboxylase; graminicides; cyclohexanediones; aryloxyphenoxypropionates Abstract Acetyl-CoA carboxylase catalyses the first committed step in fatty acid (and acyl lipid) formation. The enzyme has been shown to exert a high degree of flux control for li...