ACCase is comprised of four domains- biotin carboxylase (BC), biotin carboxyl carrier protein (BCCP) and two carboxytransferases (αCT and βCT) which are located on separate subunits in heteromeric species, whereas homomeric species contain all subunits on a single polypeptide chain (Huerlimann ...
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Acetyl-CoA carboxylase catalyses the ATP-dependent carboxylation of acetyl-CoA, a rate-limiting step in fatty acid biosynthesis1,2. Eukaryotic acetyl-CoA carboxylases are large, homodimeric multienzymes. Human acetyl-CoA carboxylase occurs in two isoforms: the metabolic, cytosolic ACC1, and ACC2,...
Prasad, A.R., Bhattacharya, T.K., Chatterjee, R.N.et al.Silencing acetyl-CoA carboxylase A and sterol regulatory element-binding protein 1 genes through RNAi reduce serum and egg cholesterol in chicken.Sci Rep12, 1191 (2022). https://doi.org/10.1038/s41598-022-05204-z ...
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Overexpression of ATP-citrate lyase and acetyl-CoA carboxylase inSchizochytriumsp.aSchematic diagram ofSchizochytriumsp. ACL and ACC. The proposed enzymatic domains are marked in different colors.bPCR verification of the transformants. +: positive control, the plasmid was used as template; −: nega...
Acetyl-Coenzyme A Carboxylase alpha Entrez Gene IDs 31 (Human); 107476 (Mouse); 60581 (Rat) Alternate Names ACACA; ACACacetyl-CoA carboxylase 1; ACC1; ACC1ACC; ACCA; ACC-alpha; AcetylCoA Carboxylase alpha; Acetyl-CoA Carboxylase alpha; acetyl-Coenzyme A carboxylase alpha; EC 6.4.1.2 ...
Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic beta-cell line INS-1. The mechanism whereby long-term exposure of the beta-cell to fatty acids alters the beta-cell response to glucose is not known. We hypothesized that fatty ... Brun,Assimacopoulos-Jean...