Two molecules of this two-carbon compound are condensed into acetoacetyl-CoA (C4) by the activity of acetyl-CoA acetyltransferase (AACT) (EC 2.3.1.9), also known as thiolase II. The enzyme 3-Hydroxy-3-methyglutaryl-CoA synthase (HMGS) (EC:2.3.3.10) carries out aldol-condensation of aceto...
2013. Acetoacetyl-CoA synthetase activity is controlled by a protein acetyltransferase with unique domain organization in Streptomyces lividans. Mol Microbiol 87:152-167. http: //dx.doi.org/10.1111/mmi.12088.A.C. Tucker, J.C. Escalante-Semerena, Acetoacetyl-CoA synthetase activity is controlled...
In this work, we provide detailed mechanistic data on the regulation of AcsA activity by lysine acetylation and report an example of an enzymatically catalysed protein lysine acetylation using AcP as an acetyl-group donor by coupling Pta activity with lysine acetyltransferase activity. Results B. subt...
2. For a range of acetyl-CoA concentrations, acetyltransferase activity (nmol of [acetyl-3H]PAF min-1 mg-1 of protein) in unstimulated neutrophils from atopic asthmatic patients was significantly higher than that for normal subjects (P = 0.038) and the mean Vmax. for atopic asthmatic ...
Abbreviation: ACLY: ATP citrate lyase; PDC: Pyruvate dehydrogenase complex; ACSS2: Acyl-CoA synthetase short-chain family member 2; ACC: Acetyl-CoA carboxylase; FASN: Fatty acid synthase; IDH1/2: Isocitrate dehydrogenase 1/2, GLS1/2: Glutaminase-1/2; KATS: K (lysine) acetyltransferase; HDAC...
Abstract ATP-citrate lyase (ACLY) synthesizes cytosolic acetyl coenzyme A (acetyl-CoA), a fundamental cellular building block. Accordingly, aberrant ACLY activity is observed in many diseases. Here we report cryo-EM structures of human ACLY, alone or bound to substrates or products. ACLY forms ...
KAT Lysine acetyltransferase LIMK1 LIM domain kinase 1 LPC Lysophosphatidylcholine LPE Lysophosphatidylethanolamine MAPK Mitogen-activated protein kinase MK Megakaryocyte MLCK Myosin light chain kinase NOX NADPH oxidase O Oligomycin OCR Oxygen consumption rate PAK p21-activated kinase PAR Protease-activated re...
N‐acetyltransferase5‐fluorouracil2‐aminofluorenep‐aminobenzoic acidNacetyltransferase (NAT) activity and MichaelisMenten kinetic constants were determined in hepatocellular carcinoma and noncancerous liver tissues from thirty patients. The results derived from tissues showed that 5 rapid, 9 intermediate ...
The acetyl-CoA synthetase (ACS) pathway and acetate kinase-phosphate acetyltransferase (ACK-PTA) pathway from acetate to acetyl-CoA were investigated, and the ACK-PTA pathway showed to be more efficient for supplying acetyl-CoA. When fatty acid was used as a carbon source, acetyl-CoA supply ...
This is the first demonstration of acetyl CoA: arylamine Nacetyltransferase activity in a crustacean and could lead to the development of a shrimp model for monitoring the effect of pollution of fresh water environments on native species.doi:10.1080/02772249909358684...