Presents the identification of the genes encoding acetyl-CoA synthetase isoform I from Pyrococcus furiosus through functional overexpression in Escherichia coli. Purification and characterization of the recombinant enzyme; Reconstitution of recombinant subunits in vitro to heterotetrameric enzyme.Musfeldt...
Abbreviation: ACLY: ATP citrate lyase; PDC: Pyruvate dehydrogenase complex; ACSS2: Acyl-CoA synthetase short-chain family member 2; ACC: Acetyl-CoA carboxylase. View article Obesity, the other pandemic: linking diet and carcinogenesis by epigenetic mechanisms ...
A cDNA encoding a novel isoform of acyl-CoA synthetase (ACS6) was isolated from embryos of oilseed rape. Homology searches show it is most closely related ... Paweena,PongdontriMatthew,Hills - 《Plant Molecular Biology》 被引量: 62发表: 2001年 加载更多来源...
Human Acetyl-CoA Carboxylase 2 cDNA encoding the 280-kDa acetyl-CoA carboxylase 2 (ACC2) isoform was isolated from human liver using the polymerase chain reaction. Sequencing the cDNA re... L Abu-Elheiga,DB Almarza-Ortega,A Baldini,... - 《Journal of Biological Chemistry》 被引量: 281发...
Acetyl-CoA carboxylase, which has a molecular mass of265 kDa (ACC-c), catalyzes the rate-limiting step in the biosynthesis of long-chain fatty acids. In this study we report the complete amino acid sequence and unique features of an isoform of ACC with a molecular mass of 275 kDa (ACC-...
acetyl-CoA acyltransferase Acetyl-CoA carboxylase Acetyl-CoA Carboxylase 2 Acetyl-Coa Carboxylase-Alpha acetyl-CoA deacylase acetyl-CoA hydrolase acetyl-CoA ligase acetyl-CoA pathway acetyl-CoA synthetase acetyl-CoA thiolase Acetyl-CoA-Carboxylases ...
Acetyl-CoA is utilized by the urea cycle by reacting with glutamate yielding N-acetylglutamate, a positive regulator of ureagenesis, an allosteric activator of carbamylphosphate synthetase-1 [47,48]. Acetyl-CoA is also a glycolytic inhibitor and an essential substrate in the citric acid cycle...
The first number indicates the broad type of enzyme (1=oxidoreductase; 2=transferase; 3=hydrolase; 4=lyase; 5=isomerase; 6=ligase (synthetase)). The second and third numbers indicate subsidiary groupings, and the last number, which is unique, is assigned arbitrarily in numerical order by the...
Biotin Regulates the Genetic Expression of Holocarboxylase Synthetase and Mitochondrial Carboxylases in Rats1 Biotin is the cofactor of carboxylases [pyruvate (PC), propionyl-CoA (PCC), 3-methyl crotonyl-CoA and acetyl-CoA], to which it is covalently bound by the a... Rocío,Rodríguez-Melénde...
CoA reductase; (b) a heterologous nucleic acid encoding an acetylaldehyde dehydrogenase, acetylating (ADA); (c) a functional disruption of at least one enzyme of the native PDH-bypass selected from the group consisting of acetyl-CoA synthetase 1 (ACS1), acetyl-CoA synthetase 2 (ACS2), and...