Malonyl-CoA is a central metabolite across living organisms, serving as the common precursor for fatty acids and their derivatives, including hydrocarbons and fatty acid methyl and ethyl esters, as well as various natural products such as polyketides (for example, the red food colorant carminic ...
A new micromethod for determination of acetyl-CoA and malonyl-CoA using malonate decarboxylase is described. This enzyme catalyzes decarboxylation of malonate in a cyclic manner and produces acetate in proportion to the amount of a given acyl-CoA, such as acetyl-CoA, malonyl-CoA or propionyl-CoA...
CoA's serve as lipid precursors, energy intermediates, and mediators of post-translational modifications of proteins. Here, we present a liquid chromatography–mass spectrometry (LC-MS) approach to measure malonyl-CoA, acetyl-CoA, and succinyl-CoA in complex biological samples. Additionally, we ...
Fatty acid synthesis starts with the carboxylation of acetyl CoA to malonyl CoA byacetyl CoA carboxylase, with the consumption of ATP (Fig. 15.8). In a subsequent reaction, CoA is exchanged byacyl carrier protein(ACP) (Fig. 15.9). ACP comprises a serine residue to which a pantetheine is ...
that has AcAc–CoA synthase activity reduced the cellular energetics for the terpenoid production in engineered E. coli. The NphT7 has unique activity to synthesize AcAc–CoA from acetyl-CoA and malonyl-CoA (Okamura et al. 2010). The expression of such AcAc–CoA synthase/ligase genes with ...
In vitro, tartronic acid promoted 3T3-L1 adipocyte differentiation by increasing the protein expression of FABP-4, PPARγ and SREBP-1. Moreover, the contents of both acetyl-CoA and malonyl-CoA were significantly upregulated by treatment with tartronic acid, while the protein expression of CPT-1...
Acetyl-CoA carboxylases (ACC) are rate-limiting enzymes in de novo fatty acid synthesis, catalyzing ATP-dependent carboxylation of acetyl-CoA to form malonyl-CoA. Malonyl-CoA is a critical bi-functional molecule, i.e., a substrate of fatty acid synthase (FAS) for acyl chain elongation (...
malonyl-CoA-acetyl CoA-acyl carrier protein S-acyltransferase 中文名: 中文别名: CBNumber: CB71352606 分子式: 分子量: 0 MOL File: Mol file 化学性质安全信息用途供应商0 malonyl-CoA-acetyl CoA-acyl carrier protein S-acyltransferase化学性质
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Acetyl-CoA carboxylase Acetyl-Coenzyme A carboxylase alpha Identifiers Symbol ACACA Alt. Symbols ACAC, ACC1, ACCA Entrez 31 HUGO 84 OMIM 601557 RefSeq