Prepn. of 3-((4-bromo-2-fluorophenyl)methyl) -3,4-dihydro-4-oxo-1- phthalazineacetic acid (I) is new, and comprises reacting (II) with (III). The reaction is carried out in a protic polar solvent (IV), an aprotic polar solvent (V) or a mixt. of (IV) and (V) with an ...
The measurements show that ionization shifts the 13C signal of the carboxyl group to low field when the group is immersed in water, but to high field when it is embedded in a polar aprotic environment. This finding allows us to understand the unusual ionization shift of aspartate groups in ...
1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C....
1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C....
1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C....
1 or 2 carbon atoms, is introduced into a reaction with glycine alkyl ester, in which the alkyl part contains from 1 to 4 carbon atoms, in presence of weak inorganic base or tertiary aliphatic amine in presence of polar protic or aprotic solvent at a temperature of 60 to 120 degrees C....