This reaction can be utilized for the preparation of α-allyl, ethyl, phenyl and substituted aryl thioglycosides of sialic acid. 1H NMR and 13C NMR spectra of the crude reaction mixtures have confirmed that complete anomeric inversion occurs under the PTC condition. Adoption of tetrabutylammoni...
Conversion of methane (CH4) to high value-added multi-carbon (C2+) oxygenates, such as acetic acid (CH3COOH), is a significant pathway for the utilization of natural gas1,2,3, which typically goes through the indirect and energy-intensive syngas route with severe carbon emission and poor pro...
NMR-spectroscopic evidence of intermediate-dependent pathways for acetic acid formation from methane and carbon monoxide over a ZnZSM-5 zeolite catalyst. Angew. Chem. Int. Ed. 51, 3850–3853 (2012) Article CAS Google Scholar Cavell, K. J. Recent fundamental studies on migratory insertion into...
The strategy of designing heterogeneous porous catalysts by a post-modification method is a smart strategy to increase the catalytic power of desired catalysts. Accordingly, in this report, metal-organic frameworks based on titanium with acetic acid pend
(a) Chemical structure and schematic illustration of the synthesis of diamino tetraiodothyroacetic acid (DAT)-conjugated PLGA (lactide:glycolide 79:21). (b) 1H NMR spectra in DMSO-D6 and assignments of signals of DAT (bottom) and PLGA-DAT (top). Full size image For DAT, all the charact...
The generated PEI could react with difluoroacetic acid anhydride for 19F NMR and MRI [266]. Either, generated PEI could be used to conjugate with antitumor drug, e.g., DOX, using pH-labile hydrazone bond [267]. Further, via copolymerization of MeOx and amino-pendent Ox, positive-charged ...
To synthesize 5-FA, 5-FU was reacted with chloroacetic acid in the presence of KOH. NMR and ESI-HRMS analyses confirmed the successful conversion of 5-FU to 5-FA. In order to deliver the 5-FA to cancer cells overexpressing EGFR, it was then conjugated to tHBcAg VLNP displaying the ...
The present invention relates to novel crystalline forms of (4-{4-[5-(6-Trifluoromethyl-pyridin-3-ylamino)-pyridin-2-yl]-phenyl}-cyclohexyl)-acetic acid, sodium and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly ...
We proposed a novel compound having an activity of PGI2 receptor agonist.A phenoxyacetic acid derivative of the formula ##STR1## A is --C(R1) N.about.OR2, --CH(R)NH
2. A crystalline polymorph of 2-(5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-ylthio)acetic acid: characterized by peaks at 10.46, 18.76, and 19.83°2θ±0.1°2θ. 3. The crystalline polymorph of claim 2, further characterized by at least one further peak at 18.21 ...