Pharmacological Research 109 (2016) 119–131Contents lists available at ScienceDirectPharmacological Researchj ourna l h om epage: w ww.elsevier.com/locate/yphrsReviewAcetaminophen from liver to brain: New insights into drugpharmacological action and toxicityCarolina I. Ghanem a,b,∗ , María J....
Acetaminophen and codeine may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. If concomitant use is warranted, because respiratory depression may be greater than otherwise expected, decrease the dosage of acetaminophen and codei...
The term “pharmaceutically acceptable salt” is meant those salts in which the counterion does not contribute significantly to the toxicity or pharmacological activity of the salt, and, as such, they are the pharmacological equivalent of the free form of the API(s). A multitude of non-toxic,...
Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics [see PRECAUTIONS; Drug Interactions]. If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an...
(paracetamol) is the most common drug ingredient in the United States and only analgesic considered safe to use throughout pregnancy.1Both the American College of Obstetricians and Gynecologists2and Society for Maternal-Fetal Medicine3recommend acetaminophen as the first-line pharmacological intervention ...
Because of similar pharmacological properties, it is reasonable to expect similar risk with the concomitant use of other CNS depressant drugs with opioid analgesics [see PRECAUTIONS; Drug Interactions]. If the decision is made to prescribe a benzodiazepine or other CNS depressant concomitantly with an...
NORCO may enhance the neuromuscular blocking action of skeletal muscle relaxants and produce an increased degree of respiratory depression. Intervention Monitor patients for signs of respiratory depression that may be greater than otherwise expected and decrease the dosage of NORCO and/or the muscle relax...
Our study provides a molecular mechanism for the antinociceptive effect of acetaminophen and discloses spinal TRPA1 activation as a potential pharmacological strategy to alleviate pain. 1 King's College London, Wolfson Centre for Age-Related Diseases, London SE1 1UL, UK. 2 Department of Clinical ...
Electrophilic APAP metabolites are formed in the liver and liver afferent neurons are therefore prime candidates for the site of action. Importantly, we found that genetic or pharmacological blockade of TRPA1 does not produce hyperthermia in rodents, in agreement with an earlier report44. This ...
Pharmacological inhibition of USP25 can prevent APAP-ALI Having demonstrated that the loss ofUsp25could protect APAP overdosing, we next wanted to determine if pharmacologic inhibition could do the same so that a USP25 inhibitor-based treatment for APAP overdosing could be developed. CT1113, a pot...