Lastly, it is known that SARS-CoV-2 uses the serine protease TMPRSS2 for S protein priming before binding to ACE2 receptor, and a TMPRSS2 inhibitor has been approved for clinical use (Camostat) to block SARS-CoV-2 entry.1 The RNA expression of TMPRSS2 in Caco2, Jurkat, and activated...
26 Research on AR-12 (OSU-03012), an inhibitor of GRP78, showed decreased SARS-CoV-2 viral replication in the colon carcinoma cell line HCT116.65 Shimomura et al. also provides scientific evidence for the role of csGRP78 as a binding partner of the SARS-CoV-2 spike protein and ACE2,...
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ACE Inhibitor or Angiotensin II Receptor Antagonist Attenuates Diabetic Neuropathy in Streptozotocin-Induced Diabetic Rats. Diabetes 2006, 55, 341–348. [Google Scholar] [CrossRef] Gu, Y.; Wu, J. LC–MS/MS coupled with QSAR modeling in characterising of angiotensin I-converting enzyme inhibitory ...
SARS-CoV-2; coronavirus; spike protein; phage display; acute COVID-19 treatment; spike-hACE2 inhibitor Graphical Abstract1. Introduction SARS-CoV-2 is a beta class coronavirus with the ability for human-to-human transmission that was initially discovered and characterized in Wuhan, China, at ...
[51] LIU Xiang, HE Hua-qiang, ZHANG T C, et al. Superhydrophobic and Self-Healing Dual-Function Coatings Based on Mercaptabenzimidazole Inhibitor-Loaded Magnesium Silicate Nanotubes for Corrosion Protection of AZ31B Magnesium Alloys[J]. Chemical En...