When the endothelium was denuded of rubbing, vascular relaxation was negligible. The half-maximal effective concentration (EC50) for canelo fruit was significantly (p < 0.001) different 89 ± 1 µg/mL in intact aorta versus 490 ± 1 µg/mL in denuded endothelium (Rubbed) (Figure 7). ...