To evaluate the ability of each method to fine-map causal variants we estimated the power-FDR performance at different mapping resolutions. Specifically, for an x-kbp mapping resolution (x = 10 kbp, 100 kbp, …, 1 Mbp), a discovery was considered true (false) if the distance ...
a Heatmap of the simulated scCAS count matrix. The y-axis represents different peaks while the x-axis represents different cells. b Heatmap of the matrix enhanced by scCASE. c The boxplot of the cell-wise auPRC and auROC between the ground-truth simulated data and the data enhanced by ...
To aid the assessment and understanding of these variations, population databases such as gnomAD [1], ExAC [2], and ChinaMap [3] have been established. Additionally, genetic disease databases, e.g., ClinVar [4], OMIM [5], and HGMD [6], have also amassed a large amount of information...
S13). Some SNVs occurred in established CRC driver genes, such as APC, BRAF, BRCA2, LRP1B, and MAP2K4, although they were intronic. In the ML tree estimated by CellPhy using the genotype likelihoods (“CellPhy-GL” model) (Fig. 6A), cells tended to group according to their ...
I was talking about the planets with my 5-year-old daughter the other day. I was trying to explain how taking a summer vacation to Mars in the future will be a much bigger undertaking than a trip to Palm Springs (though equally as hot). I kept
This can provide crucial hints when the eventual goal is to map a read to (or near) its point of origin with respect to the reference, as is the goal for tools like MashMap [5]. Past efforts have considered how to extend MinHash to include information about multiplicities, essentially ...
When you use File Explorer to view the properties of a deduplicated file, you will see that Size shows the logical size of the file, and Size on Disk shows the true physical allocation to that file. Size on Disk is less than the actual file size because deduplication has moved the ...
can be used with map-reduce very easily because digests can be merged requires no dynamic allocation after initial creation (MergingDigestonly) has no runtime dependencies Recent News There is anew article (open access!)in Software Impacts on the t-digest, focussed particularly on this reference...
STAR 2.5.3a32 with default parameters was used to map filtered reads to the Ensembl release 75 mouse reference genome. Aligned reads were normalized by library size to fragments per kilobase of transcript per million mapped reads (FPKM) using the fpkm function in the DESeq2 package in R. ...
The map of 𝜎𝑖𝑚σim in blocks (magnified by 5 for better visualization) for the test image “Frisco” (Figure 3a) is presented in Figure 10a, whereas Figure 10b shows the map of 𝜎𝑑𝑖𝑠𝑡σdist in blocks (magnified by 28 for better visualization) for the same test imag...