including extreme variations in single cell lineage progeny. Here we develop a reproducible, quantitative approach to pooled genetic perturbation in patient-derived xenografts (PDXs), by encoding single cell ou
The advances in single-cell RNA sequencing (scRNA-seq) technologies make it possible to record the temporal dynamics of gene expression over multiple time points or stages either in the same cell population [1,2] or even in an individual cell without destruction [3]. Unlike the single time p...
rc: Chain Replication Database for KVS ringo: Ringo is an experimental, distributed, replicating key-value store based on consistent hashing and immutable data. Unlike many general-purpose databases, Ringo is designed for a specific use case: For archiving small or medium-size data items. rocker...
Replication Not applicable, no experimental work is described in this study. The results are the output of a computational method which will be made available. Randomization Not applicable, we are not making a comparison between two groups Blinding Not applicable, we are not making a comparison ...
Point mutations and deletions are the two most frequent types of mutations that arise in mtDNA genome with age mainly due to spontaneous errors during mtDNA replication or damage repair. A wealth of supportive evidence demonstrates that mitochondrial dysfunction occurs with age due to accumul...