2,3,4,5,6]. Understanding this somatic mosaicism has applications in multiple areas of biology due to its intrinsic connection to development, aging, and disease [7,8]. However, the analysis of single-cell genomic
2,3,4,5,6]. Understanding this somatic mosaicism has applications in multiple areas of biology due to its intrinsic connection to development, aging, and disease [7,8]. However, the analysis of single-cell genomic
which are the culmination of distinct amalgamations of two distinct features or the distribution of one specific feature. In the case of the original features, the importance is derived from LightGBM. As for the combined features, which were hard to interpret in biology, we employ an average im...
in the copy-number segment with a VAF between i/20 and (i + 1)/20 where i is an integer between 0 and 19; count, the total number of variants to classify in that sample; ACC, CTT, etc, trinucleotide context; non-SBS-y, non-single-base substitution (meaning no trinucleotide co...
[2014] in CM). The evolution of factors might confer a survival advantage, such as the ability for a cell to disseminate beyond the primary site or development of resistance to treatment, meaning that subclones might exist not only within a single-tumor mass but also be shared by primary ...
Secondhand Science is a weekly aliquot of science humor, with topics in biology, chemistry and physics under the comedy microscope.
From the above definition of translation, we know that expressions of intent must be accurate, as far as possible to not be added to and deleted. Translator's task is only changing vocabulary rather than to change its meaning. Therefore, there are two elements: translation accuracy and expressi...
Ensemble predictors such as the random forest are known to have superior accuracy but their black-box predictions are difficult to interpret. In contrast, a generalized linear model (GLM) is very interpretable especially when forward feature selection is used to construct the model. However, forward...
In addition, during comparisons between two sets of hashes, the relative order of any shared hashes must also be considered, meaning simple set comparison is no longer enough. A practical limitation of approaches that include ordering in similarity comparison is that they may not be completely ...
Bulk RNA sequencing provides the opportunity to understand biology at the whole transcriptome level without the prohibitive cost of single cell profiling. Advances in spatial transcriptomics enable to dissect tissue organization and function by genome-wi