Lactate and ammonia accumulation is a major factor limiting the performance of fed‐batch strategies for mammalian cell culture processes. In addition to the detrimental effects of these by‐products on production yield, ammonia also contributes to recombinant glycoprotein quality deterioration. In this ...
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Evidence have shown that rats born to DEX-treated mothers are prone to accumulate high levels of TGs when exposed to high-caloric, fat-enriched diets during adult life12,13. It is still uncertain if metabolic programming by prenatal DEX exposure is also characterized by an impaired adaptation of...
Interestingly, TBM elicits autophagy by ROS-induced activation of AMPK and blocks autophagic flux by impairing the degradation of the autophagolysosome, which contributes to TBM-induced anti-cancer activity. Notably, as an autophagy modulator, TBM synergistically suppresses CRC cell growth with 5-FU ...
HIF-1α/SCD1 axis contributes to the accumulation of LDs. These results suggested that HIF-1α can be targeted in lung cancer to block the activation of CAFs and provide insights into the mechanism of HIF-1α-induced activation of CAFs....
A metabolomics study on the ischaemic heart identifies succinate as a metabolite that drives the production of reactive oxygen species and contributes to ischaemia-reperfusion injury; pharmacological inhibition of succinate accumulation ameliorates ischa
Though preservation techniques have been greatly improved, ischemia/reperfusion injury resulting in primary liver nonfunction still poses significant clinical problems and contributes to mortality[1-2]. Jaeschke et al[3-6] established that there were two distinct phases of liver injury after warm ...
During maximal exercise lactate taken up by the human brain contributes to reduce the cerebral metabolic ratio, O2/(glucose + 1/2 lactate), but it is not known whether the lactate is metabolized or if it accumulates in a distribution volume. In one experiment the cerebral arterio‐venous ...
Across the spectrum of cardiovascular diseases, suppression of the IRE1α/Xbp1s arm of the UPR is an alteration unique to HFpEF. Indeed, restoring Xbp1s in HFpEF cardiomyocytes substantially ameliorates the syndrome in mice9,10. Looking forward, how disruption of the UPR contributes to lipotoxic ...
pMLKL and MLKL immunoblot signals (relative to thet = 6 h time point value) acrossn = 4 independent experiments. Mean ± SD. Right-handy-axis plots the extracellular release of lactate dehydrogenase (LDH) as an index of plasma membrane lysis (relative to detergent-treated ...