This mode of action further suggests that acamprosate exhibits neuroprotective properties. In rats, cue-induced reinstatement behavior is significantly reduced by acamprosate treatment whereas cue-induced craving responses in alcohol-dependent patients seem not to be affected by this treatment. An ongoing ...
Acamprosate, in distinction to other approved pharmacotherapies such as naltrexone, nalmefene and disulfiram, lacks an established molecular mode of action. Previous studies have suggested that acamprosate interacts with both inhibitory and excitatory neurotransmission to restore the ethanol-induced imbalance...
High-resolution separation was done using an Acquity UPLC system and injecting 1 ml of derviatized solution, with a UPLC BEH C18 column (Milford, MA, USA). Mass detection was completed on a TSQ Ultra Quantum running in ESI-positive mode (Thermo Scientific, Waltham, MA, USA). Assessment...