Importantly, IFN-γ impeded Sp1 binding to the MUC5AC promoter. These results suggest that IFN-γ represses MUC5AC expression, disturbing binding of Sp1 to its target sequences.doi:10.1016/j.alit.2016.05.005Oyanagi, TakahitoTakizawa, Takumi...
5g). To further confirm this binding site, we performed chromatin immunoprecipitation with a ChIP-grade anti-Sp1 antibody and revealed a fourfold increase in the binding of Sp1 to the MUC5AC promoter in cells treated with CCL2 than in untreated controls (Fig. 5h). As CCR2, the cognate ...
According to the TGF-α promoter sites on the genome in the pubmed, the TGF-α promoter contains the sequence of GCGTG (Fig.S2), which was the AhR-binding sites (Patil et al., 2022). Thus, it is likely that AhR directly binds to the TGF-α promoter after BaP treatment. In ...
Interestingly, c-Ets1 also suppressed IL-1β-induced MUC5AC gene expression in vitro and in vivo by disrupting the interaction of NF-κB with CREB on the MUC5AC promoter. In addition, c-Ets1 also inhibited significant morphologic changes and inflammatory cell infiltration after IL-1β ...
MUC5AC was deemed to be involved in gastric carcinogenesis since aberrant MUC5AC expression has been repeatedly detected in patients with gastric cancer (GC). In this study, length polymorphisms in a complicated repetitive region adjacent to MUC5AC promoter were assessed in 230 patients with GC ...
MUC5AC was deemed to be involved in gastric carcinogenesis since aberrant MUC5AC expression has been repeatedly detected in patients with gastric cancer (GC). In this study, length polymorphisms in a complicated repetitive region adjacent to MUC5AC promoter were assessed in 230 patients with GC ...
MUC5AC was deemed to be involved in gastric carcinogenesis since aberrant MUC5AC expression has been repeatedly detected in patients with gastric cancer (GC). In this study, length polymorphisms in a complicated repetitive region adjacent to MUC5AC promoter were assessed in 230 patients with GC ...
promoter cellular response to estradiol stimulus DNA repair DNA recombination cell cycle multicellular organism development cellular response to insulin stimulus negative regulation of cell proliferation biological_process nucleosome disassembly inflammatory response plasminogen activation spermatogenesis, exchange of ...
TGFβ-activated Smad3 dose-dependently bound to MUC5AC promoter. Notably, TGFβ-activated Smad3 recruited HDAC2 and facilitated nuclear translocation of HDAC2, thereby inducing the deacetylation of NF-κB at K310, which is essential for a reduction in NF-κB transcriptional activity. Both TGFβ...
promoter. ConcIusions: 1.Thyroid hormonecandecreasethelevelofMUC5AC protein and mRNA respectively in the airwayepithelial cellsA549 by ELISAand RT_PCR. 2.Weconstructed aseries ofluciferase reporter geneplasmids containing different length ofhumanMUC5AC ...