本发明提供了Ac-PHSCN-NH2的酸加成盐,制备Ac-PHSCN-NH2的酸加成盐的方法,Ac-PHSCN-NH2的酸加成盐的药物组合物,利用Ac-PHSCN-NH2的酸加成盐及其药物组合物来治疗与血管生成和异常血管化相关的疾病的方法,以及通过盐形式来预防Ac-PHSCN-NH2降解的方法....
A novel anti-angiogenic/anti-metastatic peptide, ATN-161 (Ac-PHSCN-NH2), which targets multiple fully activated integrins including alpha-5 beta-1 and alpha-v beta-3, leads to increased anti-tumor activity and increased survival in multiple tumor models when combined with chemotherapy. Eur J ...
学术范收录的Journal Pharmacology of the Novel Antiangiogenic Peptide ATN-161 (Ac-PHSCN-NH2): Observation of a U-Shaped Dose-Response Curve in Several Preclinical Models of Angiogenesis and Tumor Growth,目前已有全文资源,进入学术范阅读全文,查看参考文献
本发明提供了Ac-PHSCN-NH2的酸加成盐,制备Ac-PHSCN-NH2的酸加成盐的方法,Ac-PHSCN-NH2的酸加成盐的药物组合物,利用Ac-PHSCN-NH2的酸加成盐及其药物组合物来治疗与血管生成和异常血管化相关的疾病的方法,以及通过盐形式来预防Ac-PHSCN-NH2降解的方法. The present invention provides a Ac-PHSCN-NH 2 acid...
(2006). Phase 1 trial of the antiangiogenic peptide ATN-161 (Ac-PHSCN-NH2), a beta integrin antagonist, in patients with solid tumours . Br. J. Cancer 94 , 1621–1626.10.1038/sj.bjc.6603171 [ Cross Ref ]Cianfrocca ME, Kimmel KA, Gallo J, Cardoso T, Brown MM, Hudes G, . ...
Acid addition salts of Ac—PHSCN—NH2, methods of making acid addition salts of Ac—PHSCN—NH2, pharmaceutical compositions of acid addition salts of Ac—PHSCN—NH2, methods of using acid addition salts of Ac—PHSCN—NH2 and pharmaceutical compositions thereof to treat diseases associated with ...
Acid addition salts of Ac-PHSCN-NH2, methods of making acid addition salts of Ac-PHSCN-NH2, pharmaceutical compositions of acid addition salts of Ac-PHSCN-NH2, methods of using acid addition salts of Ac-PHSCN-NH2 and pharmaceutical compositions thereof to treat diseases associated with ...
Acid addition salts of Ac—PHSCN—NH 2 , methods of making acid addition salts of Ac—PHSCN—NH 2 , pharmaceutical compositions of acid addition salts of Ac—PHSCN—NH 2 , methods of using acid addition salts of Ac—PHSCN—NH 2 and pharmaceutical compositions thereof to treat diseases ...
salt of Ac-PHSCN-NH and abnormal angiogenesis and angiogenesis a method of preventing degradation of Ac-PHSCN-NH by salt formation and methods of using the pharmaceutical compositions thereof and acid addition salts of Ac-PHSCN-NH for the treatment of diseases that are associated herein is ...
Plunkett ML, Mazar AP. Dose and schedule optimization of a novel anti-angiogenic/anti-metastatic peptide, ATN-161 (Ac-PHSCN-NH2), which targets mutiple fully activated integrins including alpha-5 beta-1 and alpha-v beta-3. Eur J Cancer. 2002; 38 Suppl 7:82....