The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell 2017, 8, 675-685. [CrossRef] [PubMed]Xu, M., X. Zhu, J. Yu, J. Yu, S. Luo, and X. Wang. 2017. The crystal structure of...
www.nature.com/scientificreports OPEN From crystal structure of α-conotoxin GIC in complex with Ac-AChBP to molecular received: 31 July 2015 determinants of its high selectivityaccepted:11February2016 for α3β2 nAChRPublished:01March2016 Bo Lin1,*, Manyu Xu2,*, Xiaopeng Zhu1,Yong...
The structure reveals that binding of DHE to AChBP imposes closure of the C-loop as agonists, but also a shift perpendicular to previously observed C-loop movements. These observations suggest that DHE may antagonize the receptor via a different mechanism compared to prototypical antagonists and ...
(-CTx) LvIA 作为迄今为止知道的 32 nAChRs 的最选择的禁止者被识别了,并且它能把 32 nAChR 子类型与 6/323 和 34 种 nAChR 子类型区分开来.然而,它向 32 的选择的机制, 6/323,和 34 nAChRs 留下逃犯.这里,我们在 3.4 的一个决定与 Aplysia californica 醋胆素绑定蛋白质(Ac-AChBP ) 在建筑群报导...
The crystal structure of Ac-AChBP in complex with α-conotoxin LvIA reveals the mechanism of its selectivity towards different nAChR subtypes. Protein Cell 2017, 8, 675-685. [CrossRef] [PubMed]Xu, M., X. Zhu, J. Yu, J. Yu, S. Luo, and X. Wang. 2017. The crystal structure of...
Acetylcholine-binding proteins from Aplysia californica (Ac-AChBP) are homologous to the ligand-binding domains of nAChRs and pharmacologically similar. X-ray structures of the α-conotoxin in complex with Ac-AChBP in addition to computer modeling h...