Useful for skin and skin structure infections when some Gram (-) and anaerobic coverage is also desirable (bite, mixed abscess). Not recommended for S. aureus bacteremia or endocarditis. Cefazolin A first-generation cephalosporin antibiotic with excellent general Gram+ activity except for enterococci...
Source control is essential. The open abdomen approach is occasionally necessary for severe infections. On-demand re-laparotomy rather than a planned re-laparotomy may be associated with better results in selected cases. If there is no clinical response within 3-5 days of antibiotic therapy and dr...
Comment:This meta-analysis explored the benefit of antibiotics for managing cutaneous abscess post-I&D. Four studies (n=2,406 participants) were identified. There were 89 treatment failures (7.7%) in the antibiotic group and 150 (16.1%) in the placebo group. There was also a decreased incidenc...
Short-course antibiotic therapy for critically ill patients treated for postoperative intra-abdominal infection: the DURAPOP randomised clinical trial. Intensive Care Med. 2018;44(3):300-310. [PMID:29484469] Comment: Short course (8 days) antibiotic therapy in post-operative intra-abdominal ...
Brucella (in combination with antibiotic), hydroxychloroquine is preferred FORMS FORMS FORMS brand name preparation manufacturer route form dosage^ cost* Aralen phosphate Chloroquine phosphate ~Various generic manufacturers PO tab 250 mg $2.82 PO tab 500 mg $7.32-14.75 *Prices represent the specified co...
Brucella (in combination with antibiotic) FORMS FORMS FORMS brand name preparation manufacturer route form dosage^ cost* Plaquenil Hydroxychloroquine sulfate Multiple manufacturers PO tablet 200 mg $1.83-12.54 *Prices represent cost per unit specified, are representative of "Average Wholesale Price" (AWP...
Antibiotic treatment and factors influencing short and long term outcomes of acute exacerbations of chronic bronchitis. Thorax. 2006;61(4):337-42. [PMID:16449273] Comment: Patients with AECB were randomized to treatment with moxifloxacin or placebo. Clinical cure wa...
Secondary cases of bacterial conjunctivitis following viral conjunctivitis are very rare; hence no reason to prescribe antibacterial drops or ointment for viral conjunctivitis. Steroids: there is no role in using steroid eye drops or antibiotic/steroid drop combinations to treat conjunctivitis in the prim...