2022年7月，中国科学技术大学朱书教授与王育才教授团队在Nature Biomedical Engineering 上发表了题为“Glucosylated nanoparticles for the oral delivery of antibiotics to the proximal small intestine protect mice from gut dysbiosis”的文章。该文开发了一种新型口服抗生素递送载体-糖基化修饰的阳离子纳米颗粒(PGNPs...
(IL-7). The expression of the IL-2 gene in mature thymocytes is monoallelic, which represents an unusual regulatory mode for controlling the precise expression of a single gene. The targeted disruption of a gene similar to IL-2 in mice leads to an ulcerative colitis-like disease...
lipase (MAGL) inhibitor. It has effective inhibition of human/mouse/rat MAGL (IC50: 5.9/15/43 nM). It has not inhibitory for FAAH (IC50 > 50 μM). It also effectively and selectively blocks hydrolysis of 2-arachidonoylglycerol (2-AG) in mice (IC50: 2.5 nM, 2-AG; >50 μM, AEA...
Cannot culture in the microbiology lab. Armadillos and immunocompromised mice used to grow M. leprae for research purposes. There's more to see -- the rest of this topic is available only to subscribers. Last updated: May 11, 2023
In the initial setting, SCID mice are reconstituted with PBMCs and then infected with the HIV-1 strain JR-CSF. Mice are treated twice a day (b.i.d) for 15 days by oral gavage with 20 mg/kg of Obefazimod. Measures of viral RNA show that the oral treatment with Obefazimod is able...
基于百奥赛图自主研发并拥有完全独立知识产权的全人抗体RenMice®平台（RenMab®和RenLite®小鼠），将单抗和双抗开发技术平台、动物体内药效筛选平台、强大的临床开发能力有机整合在一起，形成了独具特色、涵盖药物研发全流程的新药研发能力。百奥赛图正在对1000多个潜在可成药的靶点进行规模化药物开发（"千鼠万抗...
In the initial setting, SCID mice are reconstituted with PBMCs and then infected with the HIV-1 strain JR-CSF. Mice are treated twice a day (b.i.d) for 15 days by oral gavage with 20 mg/kg of ABX464. Measures of viral RNA show that the oral treatment with ABX464 is able to ...
基于百奥赛图自主研发并拥有完全独立知识产权的全人抗体RenMice®平台(RenMab®和RenLite®小鼠),将单抗和双抗开发技术平台、动物体内药效筛选平台、强大的临床开发能力有机整合在一起,形成了独具特色、涵盖药物研发全流程的新药研发能力。百奥赛图正在对1000多个潜在可成药的靶点进行规模化药物开发(“千鼠万抗TM...
Furthermore, when remdesivir was given to mice to prevent and treat MERS-CoV, it demonstrated clinical improvement and reduced viral loads. On the other hand combination of lopinavir/ritonavir with interferon beta was not as effective as remdesivir and reduced viral loads but had no impact on ...
Result: The evaluation in mice and early clinical development support the rationality of the dose and formulation as well as the administration routes. The therapeutic vaccine candidate targeted the stimulation of CD4(+) and CD8(+) T-cell responses and the induction of pro-inflammatory cytokines ca...