Bcl-w and only Noxa overcomes resistance mediated by Mcl-1, Bfl-1, or Bcl-B RW Rooswinkel1,2, B van de Kooij1, M Verheij2,3 and J Borst*,1,3 The novel anticancer drug ABT-737 is a Bcl-2 Homology 3 (BH3)-mimetic that induces apoptosis by inhibiting pro-survival Bcl-2 ...
Although drugging these interactions has proven particularly challenging, intensive structure-based efforts have enabled the design of potent and cell-active BCL-2 family inhibitors. ABT-737 was among the first molecules described,5followed soon thereafter by an orally bioavailable molecule, ABT-263 (na...