family member L2 (ALDH1L2) by directly binding to its promoter (IDDF2024-ABS-0334 Figure 3. FOXO1 Induced Fatty Acid Oxidation by Targeting ALDH1L2 in vitro and in vivo. (A) Dual luciferase reporter assay with the promoter of ALDH1L2 (B and C) The mRNA and protein levels of ALDH1L2...
translocation to the nucleus, where it binds to the promoter region of the IFN-β gene, triggering its transcription and translation into type I interferons. These interferons are vital immunomodulatory factors that exert a pivotal role in the eradication of cancer cells, by acting as the indispens...
which increased PFKFB3 phosphorylation levels, causing its transformation and increased its binding with HIF-1α, then Phospho-PFKFB3 co-translocated into the nucleus together with HIF-1α by binding with importin α5, whereby nuclear HIF-1α attaches itself to HRE regions on PD-L1 promoter, up...
By integrating multi-omics sequencing data, we pinpointed FOSL2, a transcription factor, as the key downstream target of YTHDF1. YTHDF1 bound to m6A-modified FOSL2 mRNA and promoted its translation. In turn, FOSL2 is directly bound to the CXCL6 promoter and facilitates CXCL6 transcription....