The present study describes a case of a 36-year-old female patient with SCD who demonstrated abnormal changes in the white matter of the brain. The laboratory test results showed a decrease in serum vitamin B12 levels and an increase in homocysteine levels. Magnetic resonance i...
MRI imaging acquisition MRI data were obtained using a 3.0 T system (GE Discovery MR750, GE Healthcare). Three-dimensional T1-weighted, sagittal, and inversion-recovery fast spoiled gradient echo (IR-FSPGR) MRI images of the whole head, designed to optimally discriminate between brain tissues (...
These results support the idea that synaptic integrity/function in the PCC is affected during prodromal AD and has the potential of improving early detection when combined with MRI biomarkers. AD has now reached the loaded position of being recognized as a public worldwide health priority. In the...
In order to diagnose, clinicians will look for the presence of focal neurological signs and evidence of features consistent with a cerebrovascular disease on brain imaging (CT or MRI). The observable neurologic signs localizing to certain areas of the brain include hemi...
ObjectiveAge-related macular degeneration (AMD) is a serious blinding eye disease. Previous neuroimaging studies reported that AMD were accompanied by abnormalities of the brain. However, whether AMD patients were associated with functional connectivity strength (FCS) or not remains unknown. In our ...
Forty‐nine INPH patients and 26 healthy controls were imaged with MRI, including 3ヾimensional volumetric images, for automated surface‐based cortical thickness analysis across the entire brain. Gait disturbance features related to INPH were determined using the Gait Status Scale (GSS). Compared ...
Brain microstructural changes and cognitive correlates in patients with pure obsessive compulsive disorder. Brain Behav 2014; 4: 261–277. 35 Oishi K FA, van Zigl PC, Mori S. MRI Atlas of Human White Matter, Second Edition. Academic Press: Oxford, UK, 2010, pp 17–27. 36 Radua J, ...
Results: CAG patients and rats exhibited iron deposition in gastric tissue. CAG-induced ferroptosis in the stomach was characterized by decreased GPX4 and FTH levels and increased 4-HNE levels. Hepcidin, which is mainly located in parietal cells, was elevated in CAG gastric tissue. The high ...
The patients exhibited intractable seizures at three months of age and showed ID, poor visual attention, a lack of speech development, and spastic quadriplegia; in addition, brain magnetic resonance imaging (MRI) showed diffuse hypomyelination and extensive brain atrophy. Subsequently, several studies...
However, significant white matter degeneration was not observed in the brain of the SPG7 case. Oligodendroglial coiled bodies in the dentate nucleus and in the cerebellar white matter may indicate that altered oligodendrocytes may contribute to dentate nucleus degeneration and Int. J. Mol. Sci. ...