Error detected by MisPred routine for Conflict 1: the case of the Swiss-Prot entry YL15_CAEELThe hypothetical homeobox protein C02F12.5 [EnsEMBL: C02F12.5] predicted for chromosome X contains an extracellular Kunitz_BPTI domain but was found to lack both a signal peptide and transmembrane helic...
Left ventricular biopsies from patients with DCM showed heterogeneous down-regulation of Cx43 expression, with a greater loss in the IDs compared to the lateral sides [54], [64], [65]. In small areas of replacement fibrosis there was a redistribution of Cx43, whereas in areas distant from ...
A resistant state to insulin/IGF-I in neurons is brought about when high levels of Abeta antagonizes insulin and IGF-I binding to their corresponding receptors facilitating a homeostatic compensatory mechanism whereby levels of insulin/IGF-I increase to rescue loss of function on target cells. In ...
Abnormal renovascular reactivity, characterized by paradoxical vasoconstriction to a reduction in renal perfusion pressure (RPP) in the autoregulatory range, increased sensitivity to renal nerve stimulation (RNS), and loss of vasodilatation to acetylcholine have all been demonstrated in ischemic acute renal...
For many diseases, the homozygous expression of a mutant protein induces a global loss of function by interference with protein trafficking or function. In contrast, the heterozygous expression of a mutant allele is sometimes sufficient to induce pathology as represented by a diverse set of chronic,...
loss ofRspondin 1, an agonist of WNT signalling, leads to impairment of germ cell proliferation and meiosis30. Constitutive activation of WNT signalling by stabilization of βcatenin also causes germ cell deficiency through decreasing primordial germ cell proliferation at the G1/S phase of the cell...
Moreover, it was discovered that the MAPK pathway’s MEK5-ERK5 is necessary for the survival and growth of SCLC cell lines both in vivo and in vitro and that its loss compromises lipid metabolism pathways like the mevalonate pathway, which regulates the synthesis of cholesterol [148]. In ...
An overlap can also be used in time windows, e.g., an overlap of 50%50% is used to avoid information loss in [75]. There mainly exist two approaches to slide time windows: (i) using a static sliding window [66,75], where a window with a fixed length is used to slide over the...
proteins translatedin silicofrom incomplete cDNAs or aberrant transcripts are quite abundant in this database. A recent study [33] has also revealed that alternative splicing frequently generates transcripts that encode nonviable proteins due to violation of domain integrity, loss of signal peptides, ...