Artificial "smart" molecules selectively targeted certain blood-vessel cells and prevented abnormal growth while allowing others to heal. This could lead to new stent treatments, according to preliminary research presented at the American Heart Association's Vascular Discovery Scientific Sessions 2019, a ...
By retrieving patent literature published in the last two years, small molecules patented for long-COVID-related blood clotting and hematological complications are herein examined, along with supporting evidence from preclinical and clinical studies. An overview of the main features and therapeut...
ARTICLES Abnormal TNF activity in Timp3À/À mice leads to chronic hepatic inflammation and failure of liver regeneration Fazilat F Mohammed1, David S Smookler1, Suzanne E M Taylor1, Barbara Fingleton2, Zamaneh Kassiri1, Otto H Sanchez1, Jane L English1, Lynn M Matrisian2, Billie Au1...
biochemistry of cell growth, and it emphasizes the versatility of the TCA cycle: rather than serving a purely oxidative function as a source of reducing equivalents for the electron transport chain (ETC), it can also be used as a continuous source of precursor molecules for biosynthetic pathways...
What relatively weak type of bind helps stabilize the three dimension structure of large molecules like protein or DNA? An uncontrolled diabetic, who is using fat and protein as an energy source because he cannot use glucose, may develop a condition ca...
Behcet’s disease (BD) is a chronic, systemic and recurrent inflammatory disease associated with hyperactive Th17 and Th1 immune responses. Recent studies have shown that B and T lymphocyte attenuator (BTLA) negatively regulates the immune response. In t
In Figure 4A, the level of both GLY and GABA decreased significantly after microwave exposure in PC12 cells, which was consistent with the previously observed changes in the level of these molecules in vivo [21]. Figure 4. Alteration of GABA, SYN1 and its phosphorylated proteins in PC12 cel...
In functional studies, LAMP2 KO CMs showed near-normal calcium handling at base level. However, treatment of pro-maturation medium (MM) exaggerated the disease phenotype in the KO cells as they exhibited impaired calcium recycling and increased irregular beating events, which recapitulates the pro-...
(p< 0.001). Further linear regression showed TSH level (B = 0.1, t = 3.376,p= 0.001) and systolic blood pressure (B = 0.015, t = 2.351,p= 0.019) were risk factors for a higher body mass index (BMI). Our results demonstrate that being overweight is very frequent among patients with...