Atrial fibrillation (AF) is the most common sustained heart rhythm disorder, with notable impact on quality of life, morbidity and mortality1,2,3,4. Catheter ablation using thermal energy is an effective means to treat AF, even as a first-line therapy to improve quality of life and morbidity...
www.nature.com/scientificreports OPEN Ablation of the N-type calcium channel ameliorates diabetic nephropathy with improved received: 19 February 2016 accepted: 16 May 2016 Published: 07 June 2016 glycemic control and reduced blood pressure Shoko Ohno1, Hideki Yokoi1, Kiyoshi Mori2, Masato...
摘要: National Heart and Lung Institute, Imperial College, Royal Brompton and Harefield Hospital, Sydney Street, London SW3 6NP, UK. s.ernst@rbht.nhs.uk关键词: atrial fibrillation ablation complex fractionated atrial electrograms pulmonary vein antrum isolation meta-analysis ...
Its prevalence increases with age(1) and it has an increased long-term risk of stroke, heart failure and all cause mortality(2). The UK's population is ageing and it has been calculated that over 0.9% of the entire NHS budget is already spent on managing AF and its consequences, ...
heart failure and all-cause mortality.2 The UK鈥檚 population is ageing and it has been calculated that over 0.9% of the entire NHS budget is already spent on managing AF and its consequences, principally that of stroke.3 Catheter ablation is the newest non-pharmacological treatment for AF. ...
There was no internationally agreed consensus on the definition of success for AF ablation until recently. In 2012, a selection of cardiologists and surgeons produced an “Expert Consensus Statement on Catheter and Surgical Ablation of Atrial Fibrillation”, on behalf of the Heart Rhythm Society (HR...
Furthermore, the off-target tissues of experimental mice, such as lungs, kidneys or heart, did not show congestion, edema or intraalveolar hemorrhage, neither the glomerulus and surrounding renal tubules showed cytoplasmic vacuolation or eosinophilic protein accumulation nor the heart tissue had ...
Electrophysiologist Dhiraj Gupta, @DhirajGuptaBHRS, from the Liverpool Heart and Chest NHS Foundation Trust, United Kingdom, tweeted "ENCOREVTmay be the most important study in EP sinceBordeaux's description in 1998 of PV triggers for AF. The excitement in the field is palpable." ...
1a). The use of an N-hydroxysuccinimidyl (NHS) ester PEG derivative, NHS-PEG4, enables a fast reaction with the most accessible and reactive ɛ-amine side chains of lysine on the surface of DT (Fig. 1b). Figure 1: PEGylation of DT and its in vitro functionality after modification....
, reactive oxygen species in the aorta, heart, and retinal/mesenteric vessels were attenuated in ablated noise-exposed mice, while microglial activation and abundance in the brain was greatly increased. Expression of phagocytic NADPH oxidase (NOX-2) and vascular cell adhesion molecule-1 (VCAM-1)...