Looking for online definition of ABL or what ABL stands for? ABL is listed in the World's most authoritative dictionary of abbreviations and acronyms
Looking for online definition of ABLH or what ABLH stands for? ABLH is listed in the World's most authoritative dictionary of abbreviations and acronyms
kinase activity; the normal (non-mutated) c-abl proto-oncogene is critical in normal myelopoiesis as it inhibits myeloid colony formation; it is mutated in 90% of patients with CML, implying that it is an active inhibitor of myeloid clonal expansion; it has been identified in AMLs and ALLs...
The module can be used in various ways: 1. Log only the exception: ABLLogger:getInstance():log("Exception occured: " + exception). 2. Log exception and messages ABLLogger:getInstance():log("Exception occured: " + exception, "Unable to locate the file"). 3. Log exception, message and ...
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Defects in stem cell renewal or progenitor cell expansion underlie ageing-related diseases such as osteoporosis. Yet much remains unclear about the mechanisms regulating progenitor expansion. Here we show that the tyrosine kinase c-Abl plays an important
摘要: Chronic myelogenous leukemia (CML) is a clonal hematopoietic stem-cell disorder characterized by the (9:22) translocation and resultant production of the constitutively activated bcr-abl tyrosine kinase. Characterized clinically by marked myeloid proliferation, it invariably terminates in an acute ...
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Of 17 TKI-resistant patients with baseline BCR-ABL > 0.1 % IS, 11 achieved a ≥ 1-log reduction in BCR-ABL % IS and 5 achieved major molecular response by 5 months. Clinical activity was seen across TKI-resistant mutations, including Y253H and V299L. Only 1 patient in accelerated ...
The two LTBMC with greater than a 1-log cellular expansion both tested BCR/ABL(—) after 28 days. In contrast, LTBMC of the CD34+DR+ populations failed to deplete BCR/ABL(+) cells in the seven cultures studied. The single CD34+DR+ LTBMC that was initiated with a BCR/ABL(-) cell...