"Aberrant gene expression in humans." PLoS Genet 11 (1):e1004942. doi: 10.1371/journal.pgen.1004942.Zeng, Y., G. Wang, E. Yang, G. Ji, C. L. Brinkmeyer-Langford, et al., 2015 Aberrant Gene Expression in Humans. PLOS Ge- netics 11: 1-20....
Aberrant methylation of promoter CpG islands of human genes has been known as an alternative mechanism of gene inactivation and contributes to the carcinogenesis in many human tumors. We attempted to determine the methylation status of 18 genes, or loci known to be frequently methylated in cancers ...
miRNAs are important regulators of gene expression that are frequently deregulated in cancer, with aberrant DNA methylation being an epigenetic mechanism involved in this process. We previously identified miRNA promoter regions active in normal mammary cell types and here we analyzed which of these promo...
KDM6B expression increases in B-cell subsets with ... JA Anderton,S Bose,M Vockerodt,... - 《Oncogene》 被引量: 1047发表: 0年 Epigenetic basis for aberrant upregulation of autoantigen genes in humans with ANCA vasculitis Antineutrophil cytoplasmic autoantibody (ANCA) causes vascular injury ...
BACKGROUND:MiR-9 is reportedly involved with many diseases, such as acute myeloid leukemia and liver oncogenesis. In the present study we investigated the molecular mechanism, including the potential regulator and signaling pathways, of MYOCD, which is the gene that in humans encodes the protein ...
Using RT-PCR, we also investigated the expression of let-7a miRNA in NSCLC cell lines (A549 and HCC 1588), a normal human lung fibroblast cell line (WI-38) and in 40 human NSCLC tissues. The 2(-ddCt) of let-7a miRNA in the blood of normal subjects and those with NSCLC was ...
展开 关键词: Fetus Humans Lung Pulmonary Fibrosis Cytoskeletal Proteins Trans-Activators Zebrafish Proteins Proto-Oncogene Proteins Gene Expression Regulation Adult DOI: 10.1016/S0002-9440(10)64282-4 被引量: 1552 年份: 2003 收藏 引用 批量引用 报错 分享 全部...
To assess the role of cell division in embryonic development, we identified changes in gene expression between oocytes and blastocysts. The results indicated that Dctn3 showed higher expression in oocytes but lower expression in the subsequent three stages, the zygote, 2-cell and 4-cell stages. ...
However, aberrant expression of N-cadherin has been found in many cancers, such as lung cancer, breast cancer, prostate cancer and squamous cell carcinoma. It is increasingly recognized that aberrant expression of N-cadherin is closely related to aspects of malignant tumor progression in humans, ...
The newly identified early hypermethylated genes are potential determinants for aberrant DNA methylation patterns in the disease course and, consequently, may contribute to disease development in humans. Early epigenetic changes are suspected drivers of malignancies and, hence, may offer the chance to ...