Smith, Nawel Bourayou, and Antonio Llombart-Cussac本刊负责人:张绪超 ;审校:李俊杰 ;翻译:张玉松 摘要 目的:2 (ClinicalTrials. govifier: 比较Abemaciclib,一种选择性细胞周期蛋白依赖性激酶4和6抑制剂,联合氟维司群与氟维司群单药治疗晚期乳腺癌(ABC)的有效性和安全性。 方法:MONARCH2研究是全球、双盲、...
Homeodomain-interacting protein kinases (HIPKs) belong to the CMGC kinase family and are closely related to dual-specificity tyrosine phosphorylation-regulated kinases (DYRKs). HIPKs are regulators of various signaling pathways and involved in the pathol
Diarrhea incidence was greatest during the first month of Verzenio dosing. In MONARCH 3, the median time to onset of the first diarrhea event was 8 days, and the median duration of diarrhea for Grades 2 and 3 were 11 and 8 days, respect...
HIPK2, and HIPK3 in vertebrates, and, additionally, HIPK4 in mammals. HIPKs belong to the CMGC group of serine/threonine kinases and are part of the dual-specificity tyrosine phosphorylation-regulated kinase (DYRK) family. The DYRK family has been characterized ...
2b, c. The CMGC insert region is characteristic for this kinase branch, serving as a specific binding platform for signaling partners21. With 78 to 84 residues inserted in the C-lobe between canonical helixes αG and αH (colored green to orange in Fig. 1c), HIPKs possess the longest ...
2b, c. The CMGC insert region is characteristic for this kinase branch, serving as a specific binding platform for signaling partners21. With 78 to 84 residues inserted in the C-lobe between canonical helixes αG and αH (colored green to orange in Fig. 1c), HIPKs possess the longest ...
27. Bergh J, Jonsson PE, Lidbrink EK, et al: FACT: ¨An open-label randomized phase III study of fulvestrant and anastrozole in combination compared with anastrozole alone as first-line therapy for patients with receptor-positive postmenopausal breast cancer. J Clin Oncol 30:1919-1925, 201228...