本研究建议在临床实践中通过ABCD-GENE评分将临床因素及基因因素结合,以评估患者接受阿司匹林联合氯吡格雷方案的治疗效果。(相关论文Application of Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping Score for Efficacy of Clopido...
Application of Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping Score for Efficacy of Clopidogrel: Secondary Analysis of the CHANCE Trial
The A ge, B ody mass index, C hronic kidney disease, D iabetes mellitus, and CYP2C19 GENE tic variants (ABCD‐GENE) score was developed to identify patients at risk for diminished antiplatelet effects with clopidogrel after percutaneous coronary intervention (PCI). The objective of this study ...
Application of Age, Body Mass Index, Chronic Kidney Disease, Diabetes, and Genotyping Score for Efficacy of Clopidogrel: Secondary Analysis of the CHANCE Trial
Conclusions The ABCD-GENE score had significant and moderate diagnostic ability for HPR on clopidogrel in Japanese patients undergoing PCI. The predictivity was consistent across a broad spectrum of patient populations, suggesting the applicability of this novel scoring system in clinical practice world...
OBJECTIVES The aim of this study was to develop a risk score integrating cytochrome P450 2C19 loss-of-function genotypes with clinical risk factors influencing clopidogrel response that would allow the identification with more precision of subjects at risk for high platelet reactivity (HPR) and ...
METHODS AND RESULTS: In a post hoc analysis of the TAILOR-PCI, outcomes were analyzed by ABCD-GENE score and allocation to genotype-guided or conventional P2Y(12) inhibitor selection. Primary (death, myocardial infarction, or stroke) and secondary (cardiovascular death, myocardial infarction, ...
The ABCD-GENE Score for Clopidogrel ResponseP2Y(12) inhibitorsdrug-eluting stentsrisk prediction models[Display omitted]doi:10.1016/j.jcin.2020.01.228John A. BittlJACC Cardiovascular Interventions
For the 36 ALD patients, there were no associations (correlation coefficient ≤0.3 and p-value > 0.05) between measures for disease severity (Expanded Disability Status Scale (EDSS), Severity Score system for Progressive Myelopathy (SSPROM) and Timed Up-and-Go (TUG)), age nor residual peroxiso...