在纳入本研究的2923例轻型卒中或短暂性脑缺血发作患者中,共有2273 (77.76%)例患者ABCD-GENE评分<10分,以及650 (22.24%)例患者评分≥10分。在ABCD-GENE评分<10分以及≥10分的患者中,与单独服用阿司匹林的患者相比,接受阿司匹林-联合氯吡格雷药物治...
在中国轻型卒中及短暂性脑缺血发作的人群中,在ABCD-GENE评分较高的人群在阿司匹林联合氯吡格雷治疗中的获益更低。本研究建议在临床实践中通过ABCD-GENE评分将临床因素及基因因素结合,以评估患者接受阿司匹林联合氯吡格雷方案的治疗效果。
在ABCD-GENE评分<10分和ABCD-GENE评分≥10分的患者中,与单独使用阿司匹林相比,氯吡格雷-阿司匹林治疗卒中复发的危害比(HR,95% CI)分别为0.70(0.54–0.91)和0.76(0.46–1.24)。按照ABCD-GENE评分0-5分,6-24分和>24分进行分层分析,氯吡格雷-阿司匹...
Conclusions The ABCD-GENE score had significant and moderate diagnostic ability for HPR on clopidogrel in Japanese patients undergoing PCI. The predictivity was consistent across a broad spectrum of patient populations, suggesting the applicability of this novel scoring system in clinical practice world...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White...
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White...
A novel ABCD1 gene mutation in a Chinese patient with X-linked adrenoleukodystrophydoi:10.1515/jpem-2013-0441X-linked adrenoleukodystrophy (X-ALD) (OMIM: 300100) is a recessive neurodegenerative disorder caused by defects in the ABCD1 gene on chromosome Xq28. Childhood cerebral ALD (CCALD) is ...
Gene ID: 5826 种属 Homo sapiens DNA序列编号: NM_005050.4 DNA描述 Homo sapiens ATP binding cassette subfamily D member 4 (ABCD4), transcript variant 1, mRNA DNA大小: 3035 bp DNA编码区: atggcggtcgcggggcccgcgcccggagctggcgccaggcccaggttagatctgcaattt ctccagcggttcctgcagatactgaaggttttgtttccttcttggt...
X-linked adrenoleukodystrophy (ALD) is a genetic disorder of the ABCD1 gene. We aimed to treat ALD via direct intracerebral injection of lentiviral ABCD1 (LV.ABCD1). Lentiviral vectors (LVs) were injected into the brain of wild type mice to access toxici
由1)得四边形GENE是平行四边形, 。 四边形 EF 矩形 2 如图2,件A BD交DB的延长线于 .GV⊥RD FV,则AM GA ∵l_1 是10的中点 ∴1.3 是△ADM的中位线, G:1/2:1 ∵∠ABD=120° .A =60 ∠ =30 HI=-1/2HF=1 .JW=/. ∴11-(√3)/2 RD=2AR=4, EF=1/2Rt=2 . 过过 ∴S_(...