The family of ATP-binding cassette (ABC) transporters has been widely studied regarding efflux of medications at blood-central nervous system barriers. These efflux transporters include P-glycoprotein (abcb1), 'breast cancer resistance protein' (abcg2) and the various 'multidrug resistance-associated...
ABC efflux transporters are important element of BBB.ABC efflux transporters provide neuroprotection against several neurotoxins.ABC efflux transporters contribute to the pharmacoresistance against CNS drugs.Several stressors modulate the activity of ABC efflux transporters at BBB.Pathological alterations of ABC...
Indeed, overexpression of efflux ABC transporters in cancer cells or bacteria limits drug exposure and causes therapeutic failure that is known as multidrug resistance (MDR). With the discovery of functional noncoding microRNAs (miRNAs) produced from the genome, many miRNAs have been revealed to ...
The efflux of anticancer drugs mediated by ATP-binding cassette (ABC) transporters is a widely accepted mechanism for chemoresistance, but for ABCA subfamily members, which are characterized by their ability to transport lipids and cholesterol, its role in chemoresistance remains unknown. Here we ...
baumannii by, most prevalently, adeABC of the resistance/nodulation/division family. The detection rate of adeB was the highest in clinical isolates compared to others (adeFGH, adeIJk), although it varied among other strains. In this minireview, we explain the adeABC efflux gene in A. ...
Regulation of ABC Efflux Transporters at Blood-Brain Barrier in Health and Neurological Disorders(ABC外周血转运体在健康和神经系统疾病中的调节作用).pdf38页VIP 内容提供方:mkt361 大小:1.33 MB 字数:约17.71万字 发布时间:2018-04-19发布于河南
ATP-binding cassette (ABC) transporters are efflux transporters found in all organisms. These proteins are responsible for pumping xenobiotic and endogenous metabolites through extra- and intracellular membranes, thereby reducing cellular concentrations of toxic compounds. ABC transporters have been associated...
The ABC-type efflux pump MacAB was previously linked to macrolide resistance in Escherichia coli and Salmonella enterica serovar Typhimurium. The role of the MacAB homolog in antibiotic resistance of S. marcescens is currently unknown. We found that an S. marcescens mutant lacking the MacAB pump...
efflux through the membrane, given that tumor cells overexpress drug transport proteins located in the cytoplasmic membrane, including the ATP-binding cassette (ABC) transporters P-gp (P-glycoprotein, ABCB1), multidrug resistance-associated protein 1, ABCC1, and breast cancer resistance protein, ABC...
ABC transporters Children's Cancer Institute Australia for Medical Research Rights and permissions Reprints and permissions About this article Cite this article Fletcher, J., Haber, M., Henderson, M. et al. ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer 10, 147...