The microsomal triglyceride transfer protein (MTP) inhibitor BMS-201038 was a gift from Bristol Myers Squibb (New Brunswick, NJ). Lovastatin was a gift from Merck (Rahway, NJ). Cell culture Caco-2 cells were cultured in T-75 flasks (Corning Glassworks, Corning, NY) in DMEM (GIBCO, ...
The stress signals are usually triggered by the chemotherapeutics them-selves; the hypoxia is caused by insuffi cient supply of oxygen in the tumor niche [reviewed in (117) ]. Strategies to overcome the ABC-associated MDR were fi rst based on pharmacologic inhibitors. The inhibitors of ABC ...