The stress signals are usually triggered by the chemotherapeutics them-selves; the hypoxia is caused by insuffi cient supply of oxygen in the tumor niche [reviewed in (117) ]. Strategies to overcome the ABC-associated MDR were fi rst based on pharmacologic inhibitors. The inhibitors of ABC ...
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In fact, the centre of many solid tumours is very hypoxic and quiescent cells continue to survive with very limited glucose and nutrient supply, limiting the growth of actively proliferating cells. Oxygen concentration is not a limiting factor for mitochondrial respiration until it falls below 1.0 ...
Bovine placental lacto- gen, also known as bovine chorionic somatomammotro- pin, is believed to play a pivotal role in the growth and development of the foetus by coordinating the maternal metabolism and nutrient supply from the cow to the foetus [29]. The predicted se...
Indeed, glycolysis can produce ATP more rapidly than OXPHOS with an abundant glucose supply, which in cancer is not always the case. Although cancers are characterised by poor levels of perfusion, nutrient and oxygen supplies are both temporal and spatial [1]. Blood and oxygen supply is a ...