A, stereo pair of the nf-Pgp three-dimensional structure, displayed using netting at 1.0 σ (red) and 1.5 σ (yellow) above the mean density level and viewed perpendicular to the crystal plane from the more heavily stained side (corresponding to the extracellular surface). B, equivalent ...
(corresponding to the extracellular surface).B, equivalent views of the Pgp-AMP-PNP structure. Thearrowindicates the gap along one side of the central pore. The locations of the three discrete densitiesA,B, andCare indicated.C, stereo pair of a side view of Pgp-AMP-PNP with the same ...
ATP-binding cassette (ABC) type I importers are widespread in bacteria and play a crucial role in its survival and pathogenesis. They share the same modular architecture comprising two intracellular nucleotide-binding domains (NBDs), two transmembrane do
12 Using a cyclic sulfamidate (S1) derived from l-allo-Thr, we attempted to stereoselectively install the secondary amine by nucleophilic substitution with dibenzyl-l-aspartate (18) (Scheme S1). Although we previously found substitution with weakly basic, strong nucleophiles such as NaN3 to be ...
本研究论文聚焦基于3D生物打印的胆管癌芯片在药物筛选中的应用。胆管癌(CCA)因为高异质性、低生存率,迫切需要开发有效的治疗药物。然而,现有的CCA药筛模型通常无效,也是至今临床上未有针对胆管癌有效药物的重要原因。为此,作者基于牺牲打印...
(corresponding to the extracellular surface).B, equivalent views of the Pgp-AMP-PNP structure. Thearrowindicates the gap along one side of the central pore. The locations of the three discrete densitiesA,B, andCare indicated.C, stereo pair of a side view of Pgp-AMP-PNP with the same ...