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Hepatology Volume 22, Issue 4, Part 2, October 1995, Pages A312AASLD AbstractHepatocytes express an array of novel ATP-binding cassette (ABC) proteins with apparently diverse functions: N Lomri, TJ Davern, RS Brown, Jr., C Rahmaoui, RR Cavalieri, and BF Scharschmidt. Dept of Medicine, ...
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detoxified drug conjugates and endogenous metabolites25. Using a targeted CRISPR/Cas9-based screen focused on the 48 genes encoding ABC transporters in the human genome we show that only four ABC transporters are essential for AML cell growth. Among these genes,ABCA3was implicated in chemoresistance...
siRNA screen in DU-145 cells The putative GlcCer flippases identified by proteomics (ABCA3, ABCB4, ABCB10) were depleted by siRNA in DU-145 cells to investigate effects on GSL metabolism. Other protein knockdowns were also conducted, GCS, and suspected GlcCer translocases ABCB1 and ABCA12...
palustris. Conclusion: The functional screen identified specific ligands that bound to ABC transporter periplasmic binding 展开 年份: 2013 收藏 引用 批量引用 报错 分享 全部来源 免费下载 求助全文 Citeseer (全网免费下载) Citeseer core.ac.uk 相似文献 参考文献...
Our RNAi-based screen of all 73 putative T. castaneum ABC transporters revealed obvious phenotypes for ten genes (from subfamilies A, B, E, F, G and H). Interestingly, RNAi targeting members of the largest subfamily, ABCC, failed to reveal detectable phenotypes. This might be particularly du...
Show 2 more figures Tables (1) Table Extras (5) Download all Document S1. Figures S1–S7 Table S1. MAGeCK Analysis of the CRISPR Screen, Related to Figure 1 Table S2. GO Analysis of EGFP PTC-231 -Specific Hits in the CRISPR Screen, Related to Figure 1 Table S3. Nucleic Acid Seque...
RNA was extracted from CNE2-DDP or CNE2-DDP-TRIM11 KO cells using the RNeasy Mini Kit (Qiagen) according to the manufacturer’s protocol. RNA samples were quantified using a Qubit 2.0 Fluorometer (Life Technologies, Carlsbad, CA, USA), and RNA integrity was assessed with a 4200 TapeStation...