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Sulfonylureas are widely used to increase insulin secretion in patients with non-insulin-dependent diabetes. These drugs bind to the ABCC8 and the closely related ABCC9 protein, and inhibit the KIR6 potassium channel. A polymorphism in the ABCC8 gene has been associated with insulin response in ...
Aberrant GSL metabolism is pathologically associated with many diseases (1) such as GSL storage diseases (3), type II diabetes (4), atherosclerosis (5), lupus (6), asthma (7), cancer (8-10), multiple drug resistant tumours (11,12), metabolic syndrome (13), inflammation (14) and the ...
Because unsaturated fatty acids are typically elevated in diabetes, increased levels of nonsaturated lipids may significantly contribute to low HDL cholesterol in patients with diabetes. Such a pathophysiological scenario might define an important mechanistic interlink between cholesterol metabolism and diabetes...
(Ofei等,2011,Diabetes 45:881‑85)、MTNFAI、M2TNFAI、M3TNFAI、M3TNFABI、M302B、M303(Thermo Scientific, Rockford,IL)、英夫利昔单抗(infliximab)(Centocor,Malvern,PA)、聚乙二醇化赛妥珠单 抗(certolizumab pegol)(UCB,Brussels,Belgium)、抗CD40L(UCB,Brussels,Belgium)、阿 达木单抗(adalimumab)(Abbott,...
et al. A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science 316, 1491–1493 (2007). Article CAS Google Scholar Scott, L.J. et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 316, 1341–...
As a well-known anti-inflammatory agent, wide studies have demonstrated that GS possessed multiple bioac tivities including anti-diabetes,21 modulating cell cycle and inducing apoptosis of breast and lung cancer cells.20 Nepeta cataria L and Saposhnikovia divaricata (Trucz.) Schischk were ...
It was also reported that diabetes significantly down-regulated the function and expression of P-GP at the BBB of mice, leading to increases in brain distribution of phenobarbital and its efficacy/toxicity (Liu et al., 2007). The aims of this study are: (1) to simultan...
Mutations in either subunit can alter this balance and, in the case of the SUR1/KIR6.2 channels found in neurons and insulin-secreting pancreatic β cells, are the cause of monogenic forms of hyper- insulinemic hypoglycemia and neonatal diabetes. Addition- ally, the subtle dysregulation of KATP...