The ABC model comes to play as a common method used in modern CBT. In creating the ABC model, Ellis was influenced by several ancient philosophers and the stimulus-organism-response theory (S-O-R theory). S-O-R theory holds that the environment is a stimulus consisting of signs that ...
inhibit cell growth by 50% (IC50) was calculated from survival curves by the Bliss method.35 The degree of reversal of MDR (fold reversal) was calculated by dividing the IC50 for cells with the chemotherapeutic agent in the absence of alectinib by that obtained in the presence of alectinib....
The method used in this study was first described for CFTR37. Since Pdr5 exhibits a high basal ATPase activity that is not further stimulated by its substrates, as described in this study, other methods of assaying AK activity are in our opinion unsuitable. However, as seen in Fig. 8,...
Furmonertinib stands out due to its ability to inhibit drug transport without affecting protein expression. The discovery of this characteristic was validated through ATPase assays, which revealed interactions between furmonertinib and ABCB1/ABCG2. Additionally, in silico docking of furmonertinib ...
1. Introduction Despite the continuous advancement in the treatment of cancers and the progressive introduction of new protocols, including surgery, radiation therapy, combination therapy and laser therapy, chemotherapy remains the most used option. Although cancer cells are initially susceptible to ...
Although much effort has been devoted to develop new drugs for overcoming MDR, until now, still no useful method of reversing MDR, suitable for clinical use, has emerged from this large quantity of work. Some researchers have reported that proteasome inhibitors could induce apoptosis in a variety...
Therefore, to gain maximum access to the valuable data available, the author chose also to be a participant in the study. She chronicles her journey while choosing the most suitable method. The study, which was conducted as a requirement of her master's program, was eventually completed as ...
Suitability and acceptability of computerised cognitive behaviour therapy for anxiety disorders in secondary care Objective: To evaluate the suitability and acceptability of computerised cognitive behaviour therapy (CCBT).Method: Participants were patients who had been... FA Carter,CJ Bell,HC Colhoun - ...
Furthermore, a new theoretical approach and method for studying processes of change was presented. The participants were seven patients suffering from OCD with predominantly checking symptoms. Process variables (beliefs, anxiety and compulsions) were measured using idiosyncratic diaries and were analysed ...
Requisite technologies inherent in a graduate program; Concentration of Technology approach, which advocates a single course to introduce the necessary elements of technology-based instruction; Infusion of Technology approach, which espouses an alternative delivery method for technology-based instruction....