Form Liquid Purification Method Antigen affinity purification Storage Buffer PBS with 0.02% sodium azide and 50% glycerol pH 7.3. Storage Conditions Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. 20ul sizes contain 0.1% BSA. Background Informati...
分子量293kDa 细胞定位细胞膜 性状Lyophilized or Liquid 浓度1mg/1ml 免疫原KLH conjugated synthetic peptide derived from human ABCA12 亚型IgG 纯化方法affinity purified by Protein A 储存液Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4 保存条件Store at -20 °C...
Figure 1.Proposed mechanism of the CE pathway induced by apoA-I and PON1 interactions with ABCA1. apoA-I and PON1 interact with ABCA1, which leads to the formation of lipid-poor apoA-I and pre-β-HDL, which in turn react with ABCA1 to form larger discoidal HDL particles. Continuous ...
The TMDs form a transport substrate-binding cavity that can open to either the cytoplasmic leaflet or the exofacial leaflet of the cell PM. In the absence of bound nucleotide, the NBDs are far apart (open conformation) and the cavity faces the cytoplasm (left structure in diagram). When ...
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Since XLB could be converted into its LacCer form in microsomes (61), it is feasible to cross-link downstream glycosyltransferases with XLB (61). Furthermore, B3GALT1 has been shown to use GlcCer as a substrate in addition to Lc3 (64). Major differences between the XLA and XLB ...
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In the apo-closed conformation the TM helices form a tightly packed helical bundle near the cytosolic region, primarily as a result of the intracellular region of TM5 residing closer to TM1 and TM2 of the opposite ABCG2 monomer (Fig.1a–c). In the apo-closed conformation the position of ...
These two amino-acids are found well conserved in the equivalent positions in IH1 (K13) and IH2 (E285), although in this case, they are too far away to form a salt-bridge. Figure 2. The IHs and interfaces with NBDs. Alignment of the sequences of the IHs in the ABCA family and...