1 ABC转运子G亚族概述 人类基因组共包含48个具有转录活性的ABC转运子基因。根据结构域构成和氨基酸同源性,ABC 转运子可分为7个亚族:ABCA～ABCG。ABC转运子能结合ATP并利用它作为能源,跨膜转运许多分子,如离子、氨基酸、蛋白质、糖类、磷脂和药物等。真核生物ABC转运子G亚族以典型的半转运子的形式存在。半转运...
ABC转运子的识别与鉴定 IdentificationandcharacterizationofaputativeABCtransporterPltHIJKNrequiredforpyoluteorinproductioninPseudomonassp.M18 ShanghaiJiaotongUniversity,2006,GENE Abstract •AputativeABCtransportgeneclusterpltHIJKNwasidentifiedandcharacterizedwithina7.5-kbgenomeregiondownstreamoftheantibioticpyoluteorin(...
1.Transcriptional repression ofpltZ on pyoluteorinABC transporterof Pseudomonas sp. M18;假单胞菌M18株pltZ基因转录阻抑藤黄绿菌素ABC转运系统 6)ABC transporter systemABC转运体系 1.jannaschii, revealed that there was no peptide uptakeABC transporter systemin M.jannaschii缺少负责短肽摄入的ABC转运体系 ...
ABC转运蛋白(ATP Binding Cassette Transporters)是位于肿瘤细胞膜上的一个超家族转运蛋白,可通过ATP水解供能,逆浓度的将抗肿瘤药物泵出体外。这一现象被称为多药耐药机制,极大增加了肿瘤治疗的难度。近年来,科研人员基于纳米粒子构建了一系列药物载体,认为它们可通过渗透长滞留效应(Enhanced permeability and retention ef...
拟南芥ABC转运蛋白研究进展 热度: ABCTransportersandTheirFunction atthePlasmaMembrane AnneSophieKno¨llerandAngusS.Murphy AbstractTheplasmamembrane(PM)constitutestheouterboundaryoftheplant cell.Assuch,itfunctionsincommunicationwiththeneighboringcellsandwiththe ...
ABC转运子G亚族与人类疾病 维普资讯 http://www.cqvip.com
1、Identification and characterization of a putative ABC transporter PltHIJKNrequired for pyoluteorin production in Pseudomonas sp. M18Shanghai Jiaotong University,2006,GENEAbstract A putative ABC transport gene cluster pltHIJKN was identified and characterized within a 7.5-kb genome region downstream ...
促进动脉粥样硬化斑块内的胆固醇流出并通过肝脏经胆汁排出体外—胆固醇逆向转运(reverse cholesterol transport, RCT)是治疗心血管疾病的潜在靶点。作为RCT中的关键分子,ABCA1利用ATP供能将细胞内多余胆固醇主动泵出至胞外的载脂蛋白AI(apoAI)...
ABC转运子G亚族; 胆固醇运输; 脂类运输; 阿尔茨海默氏症; 心血管疾病; 入库时间 2024-04-24 22:29:36 引文网络 参考文献 引证文献 共引文献 同被引文献 二级参考文献 二级引证文献 1. 24(S)-hydroxycholesterol participates in a liver X receptor-controlled pathway in astrocytes that regu...
1.ABCA1的TMD区域在未结合ATP的情况下呈现出朝外结构(outward-facing conformation),而此前所报导的未结合ATP的其它ABC转运蛋白的TMD区域则全部呈现出朝内结构(inward-facing conformation); 2.TMD1及TMD2独立折叠(type II ABC转运蛋白的...