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To address such concerns, next-generation anti-TNFα agents that differ from the immunoglobulin G-format anti-TNFα agents that have been used to date are being developed using antibody-engineering technology. Their unique design employing novel molecular characteristics affords several advantages, such...
Results A total of 96 patients (mean [SD] age, 54.4 [11.3] years; 52 female [54.2%]; 44 male [45.8%]) entered the OLTP and received evinacumab, 15 mg/kg, intravenously Q4W, with 88 (91.7%) completing the 48-week OLTP (eFigure 2 in Supplement 2). Eight patients (8.3%) disco...
This bottleneck cannot be overcome through software optimization or specialized hardware (such as Graphics Processing Units, for example), which gave rise to the introduction of Phenomenological5 and Effective One Body (EOB)6 models for the prediction of GWs. These do not correspond to solutions of...
Chemotherapy combined with immunotherapy has improved the treatment of certain solid tumors, but effective regimens remain elusive for pancreatic ductal adenocarcinoma (PDAC). We conducted a randomized phase 2 trial evaluating the efficacy of nivolumab (nivo; anti-PD-1) and/or sotigalimab (sotiga;...
it still helped fill that RRR-shaped vacuum this past year. It makes up for its basic revenge plot with great action. The fights were tightly choreographed, making effective use of the confined spaces of its setting. There is already news of a Hollywood remake in the works, and I can't...
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本研究为一项多中心、随机、平行组、剂量设盲、III 期 LTE 研究。将在已完成研究 230LE303 或研究 230LE304(在本研究方案中称为“III 期母研究”)的持续 52 周研究治疗的受试者中开展本研究。 开始日期2024-04-22 申办/合作机构 Biogen Idec Research Ltd. ...
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