The use of cell-type specific promoters such as human synapsin (hSYN) can restrict transgene expression profiles to specific cell types or tissues [63, 64]. Other studies suggest that promoter-capsid interactions can also influence in vivo expression [65, 66]. Future studies designed to pair ...
31 By driving expression of the GFP reporter gene under a fragment of the murine truncated GFA promoter or a human synapsin promoter, we successfully restricted expression to astrocytes or neurons in the brain after AAV9 intravenous injection. Of importance, no GFP-positive hepatocytes could be ...