Yet, whether YAP activation in cardiac fibroblasts is sufficient to drive fibrosis, and how fibroblast YAP affects myocardial inflammation, a significant component of adverse cardiac remodeling, are largely unknown. In this study, we leveraged adeno-associated virus (AAV) to target cardiac fibroblasts ...
We next tested the expression of our constructs in vivo. AAV-hTCF21-FLAG-YAP or control AAV-hTCF21-GFP was administered to 4-month-old C57BL/6J wild type male mice via retro-orbital injection. To determine whether expression was selective, we first examined GFP or FLAG expression by immunof...
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