PackGene has generated AAV-based animal models that overexpress the hACE2 protein in specific organs, making them suitable for coronavirus studies including COVID-19-related studies.
Here we show that a single intramuscular injection of Adeno-Associated Virus-6 (AAV6) or AAV9 encoding a modified, N-terminal domain deleted (螖NTD) spike protein induces robust cellular immunity and provides long-term protection in k18-hACE2 transgenic mice from lethal SARS-CoV-2 challenge,...