PackGene has generated AAV-based animal models that overexpress the hACE2 protein in specific organs, making them suitable for coronavirus studies including COVID-19-related studies.
In mice serum, a high titer of anti-hACE2 antibody was detected after the AAV/hACE2 immunization and three boosters of recombinant hACE2 protein (Figure 1B). In vitro, 50% tissue culture infectious dose (TCID50) assay was performed using authentic SARS-CoV-2, and the mean 50% ...
Here we show that a single intramuscular injection of Adeno-Associated Virus-6 (AAV6) or AAV9 encoding a modified, N-terminal domain deleted (螖NTD) spike protein induces robust cellular immunity and provides long-term protection in k18-hACE2 transgenic mice from lethal SARS-CoV-2 challenge,...
钱国超目前担任凤阳国超建筑劳务有限公司法定代表人,同时担任凤阳国超建筑劳务有限公司执行董事兼总经理;二、钱国超投资情况:钱国超目前是凤阳国超建筑劳务有限公司直接控股股东,持股比例为100%;目前钱国超投资凤阳国超建筑劳务有限公司最终收益股份为100%;三、钱国超的商业合作伙伴:基于公开数据展示,钱国超与张永彩、钱帅为...