Cre-activated AAV vectors confer cell-type specific and high-level gene expression in brains of Cre knockin mice.Sandra J. KuhlmanZ. Josh Huang
Adeno-associated virus (AAV)-Cre recombinase (Cre) injection into the facial motor nucleus of floxed CNTFR伪 mice leads to genotype-dependent loss of facial MNsNancy LeeRachel RobitzRebekah J ZurbruggAdam M KarpmanAshley M...
Here, we couple Cre-mediated skeletal muscle fiber-specific Cas9 expression with myotropic adeno-associated virus-mediated sgRNA delivery to establish a system for highly effective somatic gene deletions in mice. Using well-characterized genes, we show that local or systemic inactivation of these ...
We document transduction of cells in the pineal gland following focal injections of AAV2/9-shPTEN-zsGreen into the sensorimotor or hippocampus of rats and injections of AAV2/Cre into the spinal cord of transgenic mice with a stop-flox tdT reporter. Pineal transduction was evident even when AAV...
Structural diagram of cMet in TPR-Met mice (A) and schematic of Cre-mediated knock-out of c-Met by AAV-Cre delivered subretinally in the homozygous c-Metfl/fl mice (B).Masataka, Kasaoka
GFP expression in Pv-cre mice injected with AAV-LS1L-GFP is stable for months.Sandra, J. KuhlmanZ., Josh Huang
c-Met, p-Met and RPE65 expression in c-Metfl/fl mice 14 days after AAV-GFP and AAV-Cre injections, respectively (A, C, E, G, I and K) without laser burns; and after laser burns (B, ...
Efficient fluorescent labeling of DA neurons and their axons in AAV-LSL-mCherry injected DA neuron-specific Cre mice.Karsten, TillackHelia, AboutalebiEdgar, R. Kramer
The target construct was inserted into the locus of mouse Acvr1 gene (Figure S1). Acvr1(R206H)Fl mice were crossed with Sox2-Cre mice (Jackson laboratory, C57BL/6J), where the expression of Cre recombinase in epiblasts mediates the expression of Acvr1R206H in all tissues (Acvr1(R206...