Small molecule inhibitorsp97RUVBL1/2ATAD2ATPases Associated with Diverse Cellular Activity (AAA ATPase) are essential enzymes found in all organisms. They are involved in various processes such as DNA replication, protein degradation, membrane fusion, microtubule serving, peroxisome biogenesis, signal ...
IstA对于诱导IstB ATPase 活性是必要的。IstB能够改变靶DNA的构象成S形，IstB与IstA相互作用并改变IstA的构象，从而激活IstA调控转座反应。这个研究阐述了转座反应是如何被ATP依赖的调控因子调控的。参考文献 [1] de la Gándara, Á., Spínola-Amilibia, M., Araújo-Bazán, L., Núñez-Ramírez, R., ...
Vps4 is a AAA ATPase that mediates endosomal membrane protein sorting. It is also a host factor hijacked by a diverse set of clinically important viruses, ... MJ Landsberg,PR Vajjhala,R Rothnagel,... - 《Structure》 被引量: 99发表: 2009年 The Role of Glia in Alpha-Synucleinopathies...
Author Correction: AAA ATPASES: A spiral path to unfoldingAn amendment to this paper has been published and can be accessed via a link at the top of the paper.doi:10.1038/s41594-019-0317-8Yihong YeDi XiaSpringer NatureNature Structural & Molecular Biology...
和之前的低分辨率研究一致,cryo-EM展示IstB使用了它的N端结构域形成二聚物,二聚物能够通过ATP依赖的AAA+结构域互相作用寡聚形成蛤壳型十聚物(图3e,f)。在IstB十聚物中,已知8个核苷酸结合位点采用了典型的AAA+ ATPase构象,典型特征是其中一个单体的带正电的RF和相邻的亚基中的WA、WB典型基序相互作用(图3e,g...
The AAA-type ATPase Vps4 functions with components of the ESCRT (endosomal sorting complex required for transport) machinery in membrane fission events that are essential for endosomal maturation, cytokinesis, and the formation of retroviruses. A key step in these events is the assembly of monomeric...
DNA ReplicationAmino Acid SequenceThe AAA+ superfamily of ATPases, which contain a homologous ATPase module, are found in all kingdoms of living organisms... AW T Ogura - 《Genes to Cells》 被引量: 920发表: 2010年 A common set of conserved motifs in a vast variety of putative nucleic ac...
AAA ATPasedoi:10.1007/3-540-29623-9_6001AAA ATPases form a large and extremely heterogeneous family of enzymes belonging to the AAA superfamily containing a ring-shaped NTPase domain. These enzymes are involved in a wide variety of...Springer Berlin Heidelberg...
Cycles of ATP binding/hydrolysis fuel the unfolding of protein substrates which are gripped by loops lining up the central pore of the AAA-ATPase ring. The AAA-ATPases pull on the unfolded polypeptide chain for translocation into the proteolytic cavity of the protease. Conformational changes ...
这表明,双七聚体构象可能是CLPB的静息状态;在底物存在的情况下,底物和CLPB复合物之间的相互作用促进双六聚体的形成,而双六聚体具备更高的ATPase活性,是去聚集酶的活性状态。 由于双七/六聚体复合物分子间和分子内的高度动态性,结构的整体分辨率有限,无法分析底物的具体结合细节。为了探索CLPB结合底物的分子机理,...