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2018年Wu等[33]对HCC小鼠进行10 Gy局部放疗和瘤内注射IL-12的联合治疗,观察到治疗部位及远隔部位肿瘤的消退,并显著延长了小鼠生存期。此实验中放疗联合瘤内注射IL-12增加了肿瘤浸润性DCs上MHCⅡ类和共刺激分子CD40和CD86的表达,并显著减少了髓...
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