产品名称 A-769662(A769662) AMPK(AMP活化蛋白激酶)激活剂 产品规格 5 mg 用途范围 仅做科研,不用于临床 是否进口 否 加工定制 否 商品货号 52402ES 商品规格 5 mg 生产厂家 翌圣生物科技(上海)股份有限公司 规格编码 52402ES08 最小起订量 1.00 发货地 上海 售卖区域 全国 CAS号 844499-71-...
A-769662 (A769662; A 769662)是一种强效且可逆的AMPK(AMP活化蛋白激酶)激活剂,通过影响其β亚基碳水化合物结合区和亚基残基,并非直接作用AMP结合位点的这种独特方式来活化AMPK。另外,A-769662只激活包含β1亚基的AMPK异构体。A-769662直接激活部分纯化的大鼠肝脏AMPK (EC50= 0.8 μM),并抑制原代大鼠肝细胞中脂...
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产品名称:A769662,AMPKActivator 产品型号:M60020-5s 产品展商:其它品牌 产品文档:无相关文档 简单介绍 A769662,AMPKActivator A769662,AMPKActivator的详细介绍 Product Information Chemical Name:4-hydroxy-3-(2'-hydroxy-[1,1'-biphenyl]-4-yl)-6-oxo-6,7-dihydrothieno[2,3-b]pyridine-5-carbonitrile ...
本发明属于医药应用领域,具体涉及AMPK激动剂A769662在制备治疗猪繁殖与呼吸综合征药物中的应用.本发明发现AMPK激动剂A769662能够有效抑制猪繁殖与呼吸综合征病毒的复制,可以显著减轻临床症状,降低发病率和死亡率,减少猪只组织的病毒载量,为后续研发治疗猪繁殖与呼吸综合征的药物奠定基础....
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However, in HeLa cells, which lack LKB1 but express the alternate upstream kinase calmodulin-dependent protein kinase kinase-beta, phosphorylation of AMPK and ACC in response to A-769662 still occurs. These results show that in intact cells, the effects of A-769662 are i...
Summary AMP-activated kinase (AMPK) plays a key function in maintaining cellular energy homeostasis. We recently identified and localized AMPK protein in human spermatozoa and showed that inhibition of AMPK activity significantly modified human sperm motility. Recently, AMPK has gained great relevance as...
AMPK activity assays confirmed that AICAR and A769662 activated while compound C inhibited the activity of the kinase. Potassium ions (5脳10 3 M) induced relaxations in rings without endothelium which were not affected by AICAR but significantly inhibited by A769662. TRAM-34 (10 6 M) and ...