基于此,我们设计了一种M6PR核酸适配体-多肽偶联物作为一种新型的溶酶体靶向嵌合体(Lysosome-Targeting Chimera,LYTAC),用于降解胞外IgG抗体。作为一种双功能分子,一端为核酸适配体靶向溶酶体穿梭受体M6PR蛋白,另一端为IgG的Fc域结合多肽。偶联物可以识别胞外IgG,通过M6PR介导的内...
Manohla Dargis’s take: “‘La Chimera’ sneaks up on you. Rohrwacher is a discreet virtuoso with a visual style that is appealing and demonstrably unshowy. She likes to crowd the frame, yet does so coherently, and while she uses different film f...